Mysore betel leaf is a unique variety grown in the Mysore district of Karnataka. It is native to India and has long held a place in Indian history, religion and culture. These leaves are heart shaped, tastes very hot and the leaves have a smooth texture. It has been used as an ink, stimulant, laxative, contraceptive, digestive, narcotic and a medicine for internal and external infections. Though there are over hundreds of varieties of betel leaves grown in India, “Mysore Veelyedele” surpasses all owing to its characteristics. This has very smooth and tasty leaves, popularly known as “Mysore chigurele” and is used for chewing along with areca-nut. The presence of black clay soil with moderate rainfall and temperature make Mysore veelyedele unique to that particular locality. The occurrence of rough texture and pungent taste is observed if it is grown outside this region. These unique characteristics of Mysore veelyedele are due to a combination of the inherent genetic constitution of the Mysore veelyedele and the geographical region where it is grown. These cannot be replicated by growing the same variety in areas other than Mysore.